Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Theory, Practice, and Opportunities for Central Nervous System Drug Discovery Bruce J. Melancon,†,‡,§ Corey R. Hopkins,†,∥,‡,§ Michael R. Wood,†,∥,‡,§ Kyle A. Emmitte,†,∥,‡,§ Colleen M. Niswender,†,‡,§ Arthur Christopoulos, P. Jeffrey Conn,†,‡,§ and Craig W. Lindsley*,†,∥,‡,§ †Department of Pharmacology, ‡Vanderbilt Center for Neuroscience Drug Discovery, and Vanderbilt Specialized Chemistry Center (MLPCN), Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Melbourne, Australia